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3199-3202
Oxidation of N -Hydroxyarginine Analogues by NO-Synthase: The Simple, Non Amino Acid N-Butyl N'-Hydroxyguanidine Is Almost as Efficient an NO Precursor as N -Hydroxyarginine
Sylvie Dijols,
Céline Perollier,
David Lefevre-Groboillot,
Stéphanie Pethe,
Roger Attias,
Jean-Luc Boucher,
Dennis J. Stuehr, and
Daniel Mansuy
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3203-3215
A Structure-Based Design Approach to the Development of Novel, Reversible AChE Inhibitors
Caroline Doucet-Personeni,
Philip D. Bentley,
Rodney J. Fletcher,
Adrian Kinkaid,
Gitay Kryger,
Bernard Pirard,
Anne Taylor,
Robin Taylor,
John Taylor,
Russell Viner,
Israel Silman,
Joel L. Sussman,
Harry M. Greenblatt, and
Terence Lewis
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3216-3222
Synthesis of a Tetronic Acid Library Focused on Inhibitors of Tyrosine and Dual-Specificity Protein Phosphatases and Its Evaluation Regarding VHR and Cdc25B Inhibition
Mikiko Sodeoka,
Ruriko Sampe,
Sachiko Kojima,
Yoshiyasu Baba,
Takeo Usui,
Kazunori Ueda, and
Hiroyuki Osada
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3223-3230
Three-Dimensional Quantitative Structure-Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis
Philippe Chavatte,
Saïd Yous,
Christophe Marot,
Nicolas Baurin, and
Daniel Lesieur
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3231-3243
Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6H-1,3,4-Thiadiazine Scaffold
Jörg Schröder,
Andreas Henke,
Herbert Wenzel,
Hans Brandstetter,
Hans G. Stammler,
Anja Stammler,
Wolf D. Pfeiffer, and
Harald Tschesche
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3244-3253
Synthesis and Structure-Activity Relationships of Cetiedil Analogues as Blockers of the Ca2+-Activated K+ Permeability of Erythrocytes
Craig J. Roxburgh,
C. Robin Ganellin,
Salah Athmani,
Alessandra Bisi,
Wilma Quaglia,
David C. H. Benton,
Mark A. R. Shiner,
Misbah Malik-Hall,
Dennis G. Haylett, and
Donald H. Jenkinson
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3254-3263
Quantitative Structure-Antitumor Activity Relationships of Camptothecin Analogues: Cluster Analysis and Genetic Algorithm-Based Studies
Yi Fan,
Leming M. Shi,
Kurt W. Kohn,
Yves Pommier, and
John N. Weinstein
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3264-3274
Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity
Sabrina Dallavalle,
Anna Ferrari,
Barbara Biasotti,
Lucio Merlini,
Sergio Penco,
Grazia Gallo,
Mauro Marzi,
Maria Ornella Tinti,
Roberta Martinelli,
Claudio Pisano,
Paolo Carminati,
Nives Carenini,
Giovanni Beretta,
Paola Perego,
Michelandrea De Cesare,
Graziella Pratesi, and
Franco Zunino
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3275-3282
Synthesis and Characterization of the Antitumor Activities of Analogues of Meridine, a Marine Pyridoacridine Alkaloid
Evelyne Delfourne,
Francis Darro,
Nataly Bontemps-Subielos,
Christine Decaestecker,
Jean Bastide,
Armand Frydman, and
Robert Kiss
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3283-3291
1-[2-Methoxy-5-(3-phenylpropyl)]-2-aminopropane Unexpectedly Shows 5-HT2A Serotonin Receptor Affinity and Antagonist Character
Jagadeesh B. Rangisetty,
Ma gorzata Dukat,
Cynthia S. Dowd,
Katharine Herrick-Davis,
Ann DuPre,
Sami Gadepalli,
Milt Teitler,
Curtis R. Kelley,
Najam A. Sharif, and
Richard A. Glennon
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3292-3301
Synthesis and Biological Evaluation of Sialylmimetics as Rotavirus Inhibitors
Ashmath Fazli,
Susan J. Bradley,
Milton J. Kiefel,
Clare Jolly,
Ian H. Holmes, and
Mark von Itzstein
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3302-3310
Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1
Saleem Ahmad,
Lidia M. Doweyko,
Sundeep Dugar,
Nyeemah Grazier,
Khehyong Ngu,
Shung C. Wu,
Kenneth J. Yost,
Bang-Chi Chen,
Jack Z. Gougoutas,
John D. DiMarco,
Shih-Jung Lan,
Brian J. Gavin,
Alice Y. Chen,
Charles R. Dorso,
Randy Serafino,
Mark Kirby, and
Karnail S. Atwal
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3311-3319
Indolequinone Antitumor Agents: Correlation between Quinone Structure and Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase. Part 2
Elizabeth Swann,
Paola Barraja,
Ann M. Oberlander,
Walter T. Gardipee,
Anna R. Hudnott,
Howard D. Beall, and
Christopher J. Moody
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3320-3328
Synthesis of Potential Antidipsotropic Isoflavones: Inhibitors of the Mitochondrial Monoamine Oxidase-Aldehyde Dehydrogenase Pathway
Guang-Yao Gao,
Dian-Jun Li, and
Wing Ming Keung
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3329-3333
Synthesis, Antitumor Cytotoxicity, and DNA-Binding of Novel N-5,2-Di( -aminoalkyl)-2,6-dihydropyrazolo[3,4,5-kl]acridine-5-carboxamides
Ippolito Antonini,
Paolo Polucci,
Amelia Magnano, and
Sante Martelli
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3334-3334
| Analytical Methods in Combinatorial Chemistry By Bing Yan. Technomic Publishing Company, Inc., Lancaster, PA. 2000. xv + 268 pp. 15.5 × 23.5 cm. ISBN 1-56676-809-8. $199.95.
Jan W. F. Wasley
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3334-3335
| Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery Edited by P. J. Rosenthal. Humana Press, Totowa, NJ. 2001. xi + 396 pp. 18 × 26 cm. ISBN 0-89603-670-7. $135.00.
Jonathan L. Vennerstrom
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3335-3336
| The Story of Taxol. Nature and Politics in the Pursuit of an Anti-Cancer Drug By Jordan Goodman and Vivien Walsh. Cambridge University Press, Cambridge, U.K. 2001. xiii + 282 pp. 15.5 × 23.5 cm. ISBN 0-521-56123-X. $27.95.
Carl Kaiser
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3336-3336
| New Trends in Synthetic Medicinal Chemistry. Methods and Principles in Medicinal Chemistry, Volume 7 Edited by Fulvio Gaultieri. Wiley-VCH, Weinheim, Federal Republic of Germany. 2000. xvi + 354 pp. 17 × 24.5 cm. ISBN 3-527-29799-5. DM 248.00.
Patrick J. Bednarski
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3336-3337
| High Throughput Synthesis. Principles and Practice Edited by Irving Sucholeiki. Marcel Dekker, New York. 2001. xxi + 366 pp. 15.5 × 23.5 cm. ISBN 0-8247-0256-5. $175.00.
J. Warren Beach
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3337-3337
| From Bench to Market: The Evolution of Chemical Synthesis By Walter Cabri and Romano Di Fabio. Oxford University Press, New York. 2000. xvi + 266 pp. 19 × 24.5 cm. ISBN 0-19-850383-0. $24.95.
Manfred E. Wolff
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3337-3337
| Annual Review of Pharmacology and Toxicology. Volume 41 Edited by Arthur K. Cho, Terrance F. Blaschke, Paul A. Insel, and Horace H. Loh. Annual Reviews, Palo Alto, CA. 2001. vii + 934 pp. 15.5 × 24 cm. ISBN 0-8243-0441-1. $65.00.
Joseph Weinstock
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3338-3338
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