Journal of Medicinal Chemistry
Volume 44, Issue 20 (September 27, 2001)
Copyright © 2001 American Chemical Society

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LETTERS

3199-3202

Oxidation of N-Hydroxyarginine Analogues by NO-Synthase: The Simple, Non Amino Acid N-Butyl N'-Hydroxyguanidine Is Almost as Efficient an NO Precursor as N-Hydroxyarginine Sylvie Dijols, Céline Perollier, David Lefevre-Groboillot, Stéphanie Pethe, Roger Attias, Jean-Luc Boucher, Dennis J. Stuehr, and Daniel Mansuy [Full Article - PDF]

ARTICLES

3203-3215

A Structure-Based Design Approach to the Development of Novel, Reversible AChE Inhibitors Caroline Doucet-Personeni, Philip D. Bentley, Rodney J. Fletcher, Adrian Kinkaid, Gitay Kryger, Bernard Pirard, Anne Taylor, Robin Taylor, John Taylor, Russell Viner, Israel Silman, Joel L. Sussman, Harry M. Greenblatt, and Terence Lewis [Full Article - PDF]

3216-3222

Synthesis of a Tetronic Acid Library Focused on Inhibitors of Tyrosine and Dual-Specificity Protein Phosphatases and Its Evaluation Regarding VHR and Cdc25B Inhibition Mikiko Sodeoka, Ruriko Sampe, Sachiko Kojima, Yoshiyasu Baba, Takeo Usui, Kazunori Ueda, and Hiroyuki Osada [Full Article - PDF]

3223-3230

Three-Dimensional Quantitative Structure-Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis Philippe Chavatte, Saïd Yous, Christophe Marot, Nicolas Baurin, and Daniel Lesieur [Full Article - PDF]

3231-3243

Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6H-1,3,4-Thiadiazine Scaffold Jörg Schröder, Andreas Henke, Herbert Wenzel, Hans Brandstetter, Hans G. Stammler, Anja Stammler, Wolf D. Pfeiffer, and Harald Tschesche [Full Article - PDF]

3244-3253

Synthesis and Structure-Activity Relationships of Cetiedil Analogues as Blockers of the Ca2+-Activated K+ Permeability of Erythrocytes Craig J. Roxburgh, C. Robin Ganellin, Salah Athmani, Alessandra Bisi, Wilma Quaglia, David C. H. Benton, Mark A. R. Shiner, Misbah Malik-Hall, Dennis G. Haylett, and Donald H. Jenkinson [Full Article - PDF]

3254-3263

Quantitative Structure-Antitumor Activity Relationships of Camptothecin Analogues: Cluster Analysis and Genetic Algorithm-Based Studies Yi Fan, Leming M. Shi, Kurt W. Kohn, Yves Pommier, and John N. Weinstein [Full Article - PDF]

3264-3274

Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity Sabrina Dallavalle, Anna Ferrari, Barbara Biasotti, Lucio Merlini, Sergio Penco, Grazia Gallo, Mauro Marzi, Maria Ornella Tinti, Roberta Martinelli, Claudio Pisano, Paolo Carminati, Nives Carenini, Giovanni Beretta, Paola Perego, Michelandrea De Cesare, Graziella Pratesi, and Franco Zunino [Full Article - PDF]

3275-3282

Synthesis and Characterization of the Antitumor Activities of Analogues of Meridine, a Marine Pyridoacridine Alkaloid Evelyne Delfourne, Francis Darro, Nataly Bontemps-Subielos, Christine Decaestecker, Jean Bastide, Armand Frydman, and Robert Kiss [Full Article - PDF]

3283-3291

1-[2-Methoxy-5-(3-phenylpropyl)]-2-aminopropane Unexpectedly Shows 5-HT2A Serotonin Receptor Affinity and Antagonist Character Jagadeesh B. Rangisetty, Magorzata Dukat, Cynthia S. Dowd, Katharine Herrick-Davis, Ann DuPre, Sami Gadepalli, Milt Teitler, Curtis R. Kelley, Najam A. Sharif, and Richard A. Glennon [Full Article - PDF]

3292-3301

Synthesis and Biological Evaluation of Sialylmimetics as Rotavirus Inhibitors Ashmath Fazli, Susan J. Bradley, Milton J. Kiefel, Clare Jolly, Ian H. Holmes, and Mark von Itzstein [Full Article - PDF]

3302-3310

Arylcyclopropanecarboxyl Guanidines as Novel, Potent, and Selective Inhibitors of the Sodium Hydrogen Exchanger Isoform-1 Saleem Ahmad, Lidia M. Doweyko, Sundeep Dugar, Nyeemah Grazier, Khehyong Ngu, Shung C. Wu, Kenneth J. Yost, Bang-Chi Chen, Jack Z. Gougoutas, John D. DiMarco, Shih-Jung Lan, Brian J. Gavin, Alice Y. Chen, Charles R. Dorso, Randy Serafino, Mark Kirby, and Karnail S. Atwal [Full Article - PDF]

3311-3319

Indolequinone Antitumor Agents: Correlation between Quinone Structure and Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase. Part 2 Elizabeth Swann, Paola Barraja, Ann M. Oberlander, Walter T. Gardipee, Anna R. Hudnott, Howard D. Beall, and Christopher J. Moody [Full Article - PDF]

3320-3328

Synthesis of Potential Antidipsotropic Isoflavones: Inhibitors of the Mitochondrial Monoamine Oxidase-Aldehyde Dehydrogenase Pathway Guang-Yao Gao, Dian-Jun Li, and Wing Ming Keung [Full Article - PDF]

3329-3333

Synthesis, Antitumor Cytotoxicity, and DNA-Binding of Novel N-5,2-Di(-aminoalkyl)-2,6-dihydropyrazolo[3,4,5-kl]acridine-5-carboxamides Ippolito Antonini, Paolo Polucci, Amelia Magnano, and Sante Martelli [Full Article - PDF]

BOOK REVIEWS

3334-3334

Analytical Methods in Combinatorial Chemistry By Bing Yan. Technomic Publishing Company, Inc., Lancaster, PA. 2000. xv + 268 pp. 15.5 × 23.5 cm. ISBN 1-56676-809-8. $199.95. Jan W. F. Wasley [Full Article - PDF]

3334-3335

Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery Edited by P. J. Rosenthal. Humana Press, Totowa, NJ. 2001. xi + 396 pp. 18 × 26 cm. ISBN 0-89603-670-7. $135.00. Jonathan L. Vennerstrom [Full Article - PDF]

3335-3336

The Story of Taxol. Nature and Politics in the Pursuit of an Anti-Cancer Drug By Jordan Goodman and Vivien Walsh. Cambridge University Press, Cambridge, U.K. 2001. xiii + 282 pp. 15.5 × 23.5 cm. ISBN 0-521-56123-X. $27.95. Carl Kaiser [Full Article - PDF]

3336-3336

New Trends in Synthetic Medicinal Chemistry. Methods and Principles in Medicinal Chemistry, Volume 7 Edited by Fulvio Gaultieri. Wiley-VCH, Weinheim, Federal Republic of Germany. 2000. xvi + 354 pp. 17 × 24.5 cm. ISBN 3-527-29799-5. DM 248.00. Patrick J. Bednarski [Full Article - PDF]

3336-3337

High Throughput Synthesis. Principles and Practice Edited by Irving Sucholeiki. Marcel Dekker, New York. 2001. xxi + 366 pp. 15.5 × 23.5 cm. ISBN 0-8247-0256-5. $175.00. J. Warren Beach [Full Article - PDF]

3337-3337

From Bench to Market: The Evolution of Chemical Synthesis By Walter Cabri and Romano Di Fabio. Oxford University Press, New York. 2000. xvi + 266 pp. 19 × 24.5 cm. ISBN 0-19-850383-0. $24.95. Manfred E. Wolff [Full Article - PDF]

3337-3337

Annual Review of Pharmacology and Toxicology. Volume 41 Edited by Arthur K. Cho, Terrance F. Blaschke, Paul A. Insel, and Horace H. Loh. Annual Reviews, Palo Alto, CA. 2001. vii + 934 pp. 15.5 × 24 cm. ISBN 0-8243-0441-1. $65.00. Joseph Weinstock [Full Article - PDF]

3338-3338

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